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Moreover, bidirectional communication amongst the intestine and brain has been shown to be changed in several neurodegenerative conditions including Alzheimer´s and Parkinson´s. The current presence of opioid receptors in both the intestinal tract together with central nervous system (CNS) shows that opioid medications and exorphins may modulate the gut-brain axis. Morphine, for example, has shown a dysbiotic effect on the microbial microbiota in addition to inducing a rise in