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96-17.85, =0.055). The frequencies of c.2756AG and c.66AG variants were not significantly different among patients and controls. We observed that the 3R is a risk allele for susceptibility to BC and this allele may increase the risk of metastasis in BC patients. . We observed that the TYMS 3R is a risk allele for susceptibility to BC and this allele may increase the risk of metastasis in BC patients. . Primary amenorrhea refers to the absence of menstruation in females of reproductive by age 16 when the development of secondary
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