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/or allosteric influences of protein domains relatively distant from the central gating machinery, can crucially influence the gating process. We consider here the latest advances on these issues provided by the elucidation of eag1 and erg1 three-dimensional structures, and by both classical and more recent functional studies with different members of the EAG subfamily. Copyright © 2020 Barros, de la Peña, Domínguez, Sierra and Pardo.The genetic rat models such as rats of the WAG/Rij strain and GAERS were developed as models for generali
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