https://www.selleckchem.com/pr....oducts/pf-05221304.h
We demonstrated that PRL up-regulated phospho-JAK2, phsopho-STAT5 and β-casein expression, whereas LPS caused the opposite effects, and activated SOCS3. SOCS3 overexpression interrupted the JAK2-STAT5 pathway in BMECs. With SOCS3 was silenced, LPS could not activate the JAK2-STAT5 pathway, and no inhibition of β-casein expression was observed. In conclusion, we showed that LPS activated SOCS3 in BMECs, antagonized the JAK2-STAT5 pathway via SOCS3 regulation, and ultimately reduced β-casein expression in these cells.Intracardiac ceme
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