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The VAI and LAP index were positively associated with CKD in Korean men but not in women. The VAI and LAP index were positively associated with CKD in Korean men but not in women. Diabetic nephropathy (DN) is a major complication of diabetic mellitus and usually leads to the end-stage renal disease. Inflammation-induced lipid disorders have been proposed to play an important role in the pathogenesis of DN. S100A16 is a novel adipogenic factor, but has not been investigated in DN. This study aims to explore the role of S100A16 in high gl