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ApEn technique might provide more insight into the pathophysiological processes underlying age-related brain disconnection as well as for monitoring the impact of pharmacological and rehabilitation treatments.Weak invariants are time-dependent observables with conserved expectation values. Their fluctuations, however, do not remain constant in time. On the assumption that time evolution of the state of an open quantum system is given in terms of a completely positive map, the fluctuations monotonically grow even if the map is not unital, i
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