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We report two Hong Kong children with severe generalized epidermolysis bullosa simplex (EBS), the most severe form of EBS, without a family history of EBS. EBS is a rare genodermatosis usually inherited in an autosomal dominant fashion although rare autosomal recessive cases have been reported. Genetic studies in these patients showed that the first case was due to a novel de novo heterozygous variant, c.377TG (NM_000526.5 (c.377TG, p.Leu126Arg)) in the KRT14 gene and the second case was due to a rare de novo heterozygous variant
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