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These organocatalysts effectively enable the difficult enantioselective α-alkylation of aldehydes under prebiotic problems and show activities that correlate with the selectivity of the development. Additionally, the crystallization of solitary catalysts as conglomerates opens the path for balance busting. © 2020 WILEY-VCH Verlag GmbH Co. KGaA, Weinheim.OBJECTIVE TP53 plays a crucial role in avoiding cancer tumors development. Past scientific studies in sub-Saharan Africa (SSA) reported inconcl