http://pdksignal.com/index.php..../theoretical-along-w
Reverse transcription of Alu RNA into complementary DNA (cDNA) is assumed to happen solely in the nucleus during the genomic integration site. Whether Alu cDNA is synthesized independently of genomic integration is unidentified. Alu RNA promotes retinal pigmented epithelium (RPE) demise in geographic atrophy, an untreatable sort of age-related macular deterioration. We report that Alu RNA-induced RPE deterioration is mediated via cytoplasmic L1-reverse-transcribed Alu cDNA indepen
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