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Scrum framework has a great potential to improve the training of students and to conclude pilot projects. To investigate the safety and efficacy of combined tirofiban-ozagrel therapy for treating progressive stroke patients out of thrombolytic therapy time window. This prospective, double-blind, randomized controlled study included 337 patients who had experienced an acute ischemic stroke between November 2017 and December 2018. All patients were randomized into three groups 1) the tirofiban/ozagrel group (n=113), 2) the tirofiban group (

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