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nto the complex mechanisms driving genitourinary defects allowing the association of transcriptional defects with congenital disorders.When RA Fisher, GC Williams, and WD Hamilton laid the foundations of evolutionary life history theory, they recognized elements of what became a grandmother hypothesis to explain the evolution of human postmenopausal longevity. Subsequent study of modern hunter-gatherers, great apes, and the wider mammalian radiation has revealed strong regularities in development and behavior that show additional unexpe

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