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However, when a biopsy isn't possible or even the level of structure is limited, circulating tumefaction DNA (ctDNA) may represent an alternative solution source for genotyping the tumor. Methods In the very first stage for the study, the fluid biopsy had been carried out in newly diagnosed metastatic lung adenocarcinoma patients with and without EGFR mutations to judge the concordance between EGFR mutational analysis on ctDNA by real time PCR as well as on muscle. Within the 2nd stage it absolu
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