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More, ketamine increased cortical oscillations within the gamma frequency range, which is a house associated with psychosis. Rapastinel induced comparable plasticity-related alterations in transcriptomics to ketamine in rats but differed in several gene ontology classes, some of which may be active in the regulation of sleep. In summary, rapastinel demonstrated a lowered tendency than ketamine to induce CNS-related undesirable negative effects and rest disturbances.Chronic
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