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Conversely to pathological findings, broadly HIV-1-neutralizing antibodies (BnAb) observed in several autoimmune diseases such as SLE, could exert a protective part against HIV infection. It is important to evaluate the onset of autoimmune diseases in HIV patients, in order to start the appropriate treatment to avoid harmful events. More studies are needed to enlighten the trend of autoimmune diseases during HIV infection. Pathogenic mechanisms and clinical manifestations of rheumatological diseases during HIV infection wil