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The partnership between maternal age and typical fetal chromosomal aneuploidy was observed. The sensitiveness, specificity, PPV, NPV of NIPS for detecting fetal trisomy 21 were 99.11, 99.96, 90.98, and 100%, correspondingly. These same variables for finding fetal trisomy 18 were 100, 99.94, 67.92, and 100%, respectively. Finally, these variables for detecting trisomy 13 were 100, 99.96, 27.78, and 100%, respectively. The prevalence of fetal trisomy 21 enhanced exponentially with mater