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Options for the treatment of proximal- and middle-thirds ofhumeral shaft fracturesinclude intramedullary interlocking nail (IMN) and minimally invasive plate osteosynthesis (MIPO). However, whether IMN provides better clinical outcomes than MIPO surgical technique still remains unclear. This study was designed to compare clinical outcomes of the IMN with MIPO technique for the treatment of proximal- and middle-thirds of humeral shaft fractures. A retrospective cohort analysis of 55 proximal- and middle-thirds of humeral shaft fracturess