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in future clinical studies is highly desirable. Due to lack of evidence, it is not possible to give specific recommendations for drug therapy of AD and BSPD in frail older patients or older patients with significant functional impairments. Therefore, clinical trials focussing on frail older adults are urgently required. A standardized approach to physical frailty in future clinical studies is highly desirable. Coronavirus disease 2019 has been a public health threat and a worldwide emergency for more than a year. Unfortunately, many que