https://www.selleckchem.com/pr....oducts/oss-128167.ht
mutation type was known for 102 patients (94.4%) of whom 90 (88.2%) had null mutations and 12 (11.8%) had non-null mutations. Of 105 PUPs evaluable for inhibitor development, 28 (26.7%) developed inhibitors; 17 high titre (16.2%) and 11 low titre (10.5%). No PUPs with non-null mutations developed inhibitors. In the NuProtect study, the rate of inhibitor development in PUPs with severe haemophilia A treated with simoctocog alfa was lower than the rate reported for hamster-cell-derived recombinant factor VIII products in other recent
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