https://www.selleckchem.com/pr....oducts/CP-690550.htm
To evaluate Nuclear Factor NF-κB (NF-κ signaling on microglia activation, migration, and angiogenesis in laser-induced choroidal neovascularization (CNV). Nine-week-old C57BL/6 male mice were randomly assigned to IMD-0354 treated or untreated groups (5 mice, 10 eyes per group). CNV was induced with a 532-nm laser. Laser spots (power 250mW, spot size 100μm, time of exposure 50ms) were created in each eye using a slit-lamp delivery system. Selective inhibitor of nuclear factor kappa-B kinase subunit beta (IKK2) inhibitor IMD-0354 (10μ
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