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6 years, 172 subjects developed dementia, 270 died, and 594 participants underwent anesthesia. In LMMs, exposure to anesthesia was associated with decline in cognitive function over time (change in annual cognitive -score slope = -0.063, 95% CI (-0.080, -0.046), 0.001). Accounting for informative dropout using shared parameter models, exposure was associated with greater cognitive decline (change in annual slope = -0.081, 95% CI (-0.137, -0.026), = 0.004). We revisited prior work by our group with a focus on informative dropout. Al

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