https://www.selleckchem.com/pr....oducts/monomethyl-au
Menin serves both tumor suppressor and promoter roles in a highly tumor-specific manner. In colorectal cancer (CRC) menin is over-expressed and plays a critical role in regulating transcription of SKP2, and combined treatment with a menin inhibitor (MI) and small molecule EGFR inhibitor (EGFRi) leads to synergistic killing of CRC cells. However, the full spectrum of menin function in CRC remains uncertain. Herein, we demonstrate that menin inhibition increases glycolysis in CRC cells. This MI-induced increase in gly
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