https://www.selleckchem.com/products/cb-839.html
Keratins play multiple significant biological roles in epithelium. Keratin 1 (K1)/keratin 10 (K1 heterodimer is a hallmark for keratinocyte differentiation. While keratins are absent in normal melanocyte, keratins have been found in both melanoma cell lines and human melanoma. The biological significance of the keratins in melanoma cells has remained unclear. In our current study we applied K1 siRNA to investigate the biological significance of K1 in B16-F10 melanoma cells. We found that as low as a 16% decrease in the K1 level led to
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