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Since the worst-case situation of strong cytochrome P450 (CYP) inhibitors has to be tested, the outcome and their credibility need to be balanced because of the threat to volunteer security. The application of ketoconazole in medical DDI researches has-been frustrated by regulating companies as a result of an alleged danger of liver injury. To be able to lower the threat to healthier volunteers, we done a report with single-day experience of all of 6 perpetrator azole fungista
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