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creased rate of very preterm delivery, preterm PROM or reduced neonatal survival when compared with surgery after 18 weeks. This article is protected by copyright. All rights reserved. Laser surgery prior to 18 weeks of gestation is not associated with an increased rate of very preterm delivery, preterm PROM or reduced neonatal survival when compared with surgery after 18 weeks. This article is protected by copyright. All rights reserved.Complex human diseases are affected by genetic and environmental risk factors and their interactions