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CLC was evaluated in human THP-1 macrophages. In trans women, total HDL-CEC decreased by 10.8% (95%CI -14.3;-7.3; p0.001), ABCA1 HDL-CEC by 23.8% (-34.7; -12.9; p0.001) and aqueous diffusion HDL-CEC by 4.8% (-8.4;-1.1; p0.01). In trans men, only aqueous diffusion HDL-CEC decreased significantly, -9.8% (-15.7;-3.9; p0.01). ABCG1 HDL-CEC did not change in either group. Serum CLC and HDL subclass distribution were not modified by HT in both groups. Total HDL-CEC decreased during HT in trans women, with a specific reduction

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