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A non-canonical mitophagy system has been identified, and mitochondria-eating necessary protein (MIEAP) plays a key part in this technique. We therefore hypothesized that accumulation of unusual mitochondria might be related to faulty MIEAP appearance in these tumors. We first show that MIEAP had been expressed in all the traditional thyroid follicular adenomas (FAs)/adenomatous goiters (AGs) but not in oncocytic FAs/AGs, while its appearance was faulty not merely oncocytic thyroid cance