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Background Secondary metabolites of plants, the poly phenols, play vital role in protection from many health problems in human beings. Structurally favored phytochemicals may be studied to protect multi organ injury. At pharmacological doses, gallic acid is nontoxic to mammals and is generally absorbed in the intestine. Aims In this present study, gallic acid was evaluated for its protective efficacy against lipo polysaccharide (LPS) and dgalactosamine (D-GalN) induced multiorgan injury, i.e., liver, kidney and brain. Methods Three diff