https://www.selleckchem.com/products/R406.html
Cystic fibrosis transmembrane conductance regulator (CFTR) is a chloride channel activated by PKA phosphorylation on the regulatory (R) domain. Phosphorylation at several R domain residues stimulates ATP-dependent channel openings and closings, termed channel gating. To explore the protein segment responsible for channel potentiation and PKA-dependent activation, deletion mutations were constructed by removing 1 to 3 protein segments of the R domain, including residues 708-759 (ΔR708-759), R760-783 and R784-835, each of which contains one
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