https://www.selleckchem.com/pr....oducts/protoporphyri
Alzheimer's disease (AD) is a multifactorial disease, implying that multi-target treatments may be necessary to effectively cure AD. Tetrahydrobiopterin (BH4) is an enzymatic cofactor required for the synthesis of monoamines and nitric oxide that also exerts antioxidant and anti-inflammatory effects. Despite its crucial role in the CNS, the potential of BH4 as a treatment in AD has never been scrutinized. Here, we investigated whether BH4 peripheral administration improves cognitive symptoms and AD neuropathology in the triple
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