https://p53signals.com/index.p....hp/spleen-performs-a
Coordinated domain movements of Cas9 previous to DNA cleavage being thoroughly characterized but our comprehension of Cas9 conformations postcatalysis is restricted. Because Cas9 can remain stably certain to the cleaved DNA all day, its postcatalytic conformation may influence genome editing systems. Here, we make use of single-molecule fluorescence resonance power transfer to define the HNH domain movements of Cas9 that are coupled with cleavage activit
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