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0±145.5, mean±SD), significantly lower PPT (kilopascal) values were found (estimate=124.28, 95% CI 58.98, 189.59, p0.001; effect size d=1.4. No differences between the groups were found for pain intensity and unpleasantness ratings of cold-water immersion nor the CPM response. This study found altered ascending nociceptive processing of mechanical stimuli at the neck in adolescents with migraine. However, endogenous pain modulatory mechanisms were functional and not altered. In light of other studies, impairments in inhibitory contr
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