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Additionally, SphereCon may be the only measure that yield precise results once the identities of proteins tend to be unknown. A substantial novel function of SphereCon is the fact that it could estimate RSA from inter-residue distance and contact matrices, without having any details about the particular atom coordinates. ACCESS https//github.com/kalininalab/spherecon. SUPPLEMENTARY INFORMATION Supplementary information are available at Bioinformatics online. © The

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