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We took advantage of the 2015-2016 Brazilian arbovirus outbreak (ZIKV/DENV/CHIKV), associated with neurological complications, to type HLA-DRB1/DQA1/DQB1 variants in patients exhibiting neurological complications and in bone marrow donors from the same endemic geographical region. . DRB1/DQA1/DQB1 loci were typed using sequence-specific oligonucleotides. In silico studies were performed using X-ray resolved dimer constructions. The DQA1*01, DQA1*05, DQB1*02 or DQB1*06 genotypes/haplotypes and DQA1/DQB1 haplotypes that encode the putativ