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We accept the original estimate as relevant only if its absolute value is sufficiently larger than those of randomized data sets. These manipulations suppress false positive couplings induced by statistical noise. We apply this inference procedure to spiking data from synthetic and in vitro neuronal networks. The results show that the proposed procedure identifies the presence or absence of synaptic couplings fairly well, including their signs, for the synthetic and experimental data. In particular, the results support that we can infe