https://www.selleckchem.com/pr....oducts/BMS-790052.ht
Overall, the data presented herein provide new insights that may facilitate the rational design of more efficacious 2-PAM analogs.The sirtuin enzymes are potential drug targets for intervention in a series of diseases. Efforts to inhibit enzymes of this class with thioamide- and thiourea-containing, substrate-mimicking entities have produced a number of high-affinity binders. However, less attention has been dedicated to the investigation of the stability of these inhibitors under various conditions. Here, we provide evidence of an u
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