https://www.selleckchem.com/pr....oducts/pd-1-pd-l1-in
283h , initial ManNAc to Neu5Ac conversion (SLP ) =0.000619 (ng/mL) and at steady-state (SLP ) =0.00334 (ng/mL) , with a rate-constant of increase (k ) =0.0287h . Goodness-of-fit plots demonstrated an acceptable and unbiased fit to the plasma ManNAc and Neu5Ac concentration data. Visual predictive checks demonstrated reasonable agreement between the 5th, 50th, and 95th percentiles of the observed and simulated data. This population pharmacokinetic model can be used to evaluate ManNAc dosing regimens and to calculate Neu5A
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