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These findings might be useful in the prediction of viral disease incidence in host plants and this method can also be effective to detect other viruses in their insect vectors. Use of avermectin B1b as anthelmintic and insecticidal agent has increased to protect soil and for enhanced crop production. Enhanced production of avermectin B1b was obtained from mutant strain of 41445. Modeling of mutant strain 41445 UV 45(m) 3 growth and avermectin B1b production is therefore required for optimization during fermentation process. Kinetics of intracellula

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