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Postprandial symptoms presumably related to intestinal gas production are common in patients with irritable bowel syndrome (IBS). The aim of the study was to assess if oral α-galactosidase is superior to placebo in reducing gastrointestinal (GI) symptoms and intestinal gas production after ingestion of carbohydrate-rich meals in adult patients with IBS. We studied the effect of 1200GaIU/meal α-galactosidase (Nogasin ) or placebo capsules on GI symptoms in patients with IBS after three standardized, meals high in oligosaccharides, in a