https://www.selleckchem.com/pr....oducts/pd0166285.htm
Ventricular myocytes (VM) depolarization activates L-type Ca channels (LCC) allowing Ca influx (I ) to synchronize sarcoplasmic reticulum (SR) Ca release, via Ca -release channels (RyR2). The resulting whole-cell Ca transient triggers contraction, while cytosolic Ca removal by SR Ca pump (SERCA2) and sarcolemmal Na /Ca exchanger (NCX) allows relaxation. In diseased hearts, extensive VM remodeling causes heterogeneous, blunted and slow Ca transients. Among remodeling changes are A) T-tubules disorganization. Diminished SERCA2 and lo
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