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More subvisible particles and protein aggregates were generated in formulations containing higher concentrations of IVIG, but they reached a plateau at protein concentrations above 2 mg/mL, where adsorption isotherms saturated. Negatively charged pump surfaces interacted with the positively charged IVIG to produce more particles and aggregates than positively charged surfaces, an effect ascribed to electrostatic interactions that moderated rates of protein adsorption. In this study, the processability of polyvinyl alcohol (PVA), a w