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4% response) totaling 101,231 beds in the second. Ten of the 11 criteria improved (p less then 0.05), as well as the composite indicator (p=0.001) in all the regions of the country, particularly in the group of hospitals participating at baseline. "Hand-hygiene (HH) infrastructure" reached 100% (baseline 97.9, p=0.001), "HH protocol" 96.9% (baseline 92.9, p=0.001), "HH monitoring" 70% (baseline 60.7, p less then 0.001) and "existence of antimicrobial prescription protocol" 80.7%(baseline 73.2; p less then 0.001), among others. The HAI rat

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