https://www.selleckchem.com/pr....oducts/obeticholic-a
In normotensive patients with OSA, the muscle sympathetic nerve activity (MSNA) response to exercise is increased while metaboreflex control of MSNA is decreased. We tested the hypotheses that acute intermittent hypercapnic hypoxia (IHH) in males free from OSA and associated comorbidities would augment the MSNA response to exercise but attenuate the change in MSNA during metaboreflex activation. Thirteen healthy males (age = 24 ± 4 years) were exposed to 40 minutes of IHH. Before and after IHH, the pressor response to exercise
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