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Since the incorporation of fluorine and fluorinated teams is of special interest in pharmaceutical chemistry, a selection of metal-catalyzed and organocatalyzed techniques have already been developed. Herein, we review the enantioselective fluorination, trifluoromethylation and trifluoromethylthiolation of 3-oxo esters. The range, the induction of enantioselectivity and mechanistic investigations tend to be presented.Cancers for the oral cavity cause significan
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