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Also, decreased ToCV-CP gene appearance quantities of 81.05 and 87.59% could possibly be achieved when tomato was addressed with compounds C5 and C22, correspondingly, which were clearly higher than the levels after ningnanmycin (NNM) treatment (43.88%) and lead compound Xiangcaoliusuobingmi (XCLSBM) therapy (63.56%). Therefore, this work indicates that 4(3H)-quinazolinone derivatives containing dithioacetal moiety can be used as unique anti-ToCV agents.We report a structu