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Tuberculosis (T is the leading cause of death from a single infectious agent. According to the WHO, 85% of cases in 2018 were pulmonary tuberculosis (PT, making it the most prevalent form of the disease. Although the bacillus responsible for disease, Mycobacterium tuberculosis (MT, is estimated to infect 1.7 billion people worldwide, only a small portion of those infected (5-10%) will transition into active TB. Because such a small fraction of infected people develop active disease, we hypothesized that underlying host genetic va
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