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© 2020 Wiley Periodicals, Inc.BACKGROUND In metabolically stable horses, alpha-2-agonists suppress insulin secretion with transient hyperglycemia and rebound hyperinsulinemia. In horses with insulin dysregulation (ID), the effect of alpha-2-agonists has not been investigated; however, both the alpha-2-agonist-induced suppression of insulin secretion and rebound hyperinsulinemia could have clinical relevance. HYPOTHESIS/OBJECTIVES In horses with ID, alpha-2-agonists will alter insulin and glucose dynamics. ANIMALS Seven horses with ID and
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