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BACKGROUND Cryptogenic stroke has been used to identify ischemic strokes with no identified cause; however, this classification is limited by the lack of a standardized and thorough evaluation. Embolic Stroke of Undetermined Source is used to define those strokes with no identified cause after a standardized diagnostic workup. METHODS We conducted a literature review from January 1, 2014, to July 31, 2020 including the term "ESUS." RESULTS Embolic stroke of undetermined source accounts for approximately 25% of ischemic strokes and is us
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