https://www.selleckchem.com/pr....oducts/ldc195943-imt
PURPOSE Metabolome analysis is an emerging method that provides insight into intracellular and physiological responses. Methotrexate (MTX) is an antifolate that suppresses DNA syntheses by inhibiting dihydrofolate reductase. High-dose MTX treatment with deferred radiotherapy is a standard protocol in primary central nervous system lymphoma (PCNSL) treatments. However, most cases come to relapse-acquired resistance, in which the role of metabolic pathways are largely unknown. METHODS Metabolome analysis in MTX-resistant PCNSL-deri
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