https://www.selleckchem.com/pr....oducts/skf-34288-hyd
OBJECTIVE High-grade serous ovarian cancer (HGSOC) is the most common and lethal histological subtype of epithelial ovarian cancer. HGSOC with cyclin E1 gene (CCNE1) amplification and bromodomain and extraterminal 4 (BRD4) amplification have been associated with poor outcomes. Our objective was to evaluate clinical outcomes of HGSOC with co-amplification of CCNE1 and BRD4 and high protein expression of cyclin E and BRD4. METHODS Copy number amplification data were extracted from The Cancer Genome Atlas (TCGA) for 579 HGS
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