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We would urge that clinicians take note of these findings and give strong support to widespread use of daily vitamin D supplementation. The activation of tumor-associated macrophages (TAMs) facilitates the progression of gastric cancer (GC). Cell metabolism reprogramming has been shown to play a vital role in the polarization of TAMs. However, the role of methionine metabolism in function of TAMs remains to be explored. Monocytes/macrophages were isolated from peripheral blood, tumor tissues or normal tissues from healthy donors or pati